Nipoxen

Naproxen
250 mg Tablet & 500 mg SR Tablet
Description:

Nipoxen(Naproxen) is a non steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic & antipyretic properties. It is rapidly absorbed from the gastrointestinal tract and achieves 95% bioavailability.


    Composition

    Nipoxen 250 Tablet : Each tablet contains Naproxen BP 250 mg.

    Nipoxen 500 SR Tablet : Each sustained release tablet contains Naproxen BP 500 mg.

    Indication

    Nipoxen (Naproxen) is indicated for the relief of sign and symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendonitis, bursitis & acute gout. It is also indicated for the management of primary dysmenorrhea & pain.

    Dosage & Administration

    Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis : The usual dose is 500-1000 mg daily in two divided doses after meals.

    Management of pain, primary dysmenorrhea, acute tendonitis & bursitis : Recommended starting dose is 500 mg followed by 500 mg every 12 hours or 250 mg every 6-8 hours. The initial total daily dose should not exceed 1250 mg and thereafter, the total daily dose should not exceed 1000 mg.

    Acute gout : Recommended starting dose is 750 mg followed by 250 mg every 8 hours until the attack has subsided.

    Contraindication

    Nipoxen is contraindicated in patients with known hypersensitivity to Naproxen. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

    Precaution

    Nipoxen is contraindicated in patients with known hypersensitivity to Naproxen. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

    Side Effects

    Most frequently reported side effects include following :
    Gastrointestinal : Heartburn, abdominal pain, nausea, diarrhea, dyspepsia.
    Central Nervous System :Headache, vertigo, drowsiness.
    Dermatological :Pruritus (itching), purpura.
    Cardiovascular : Edema, palpitation.
    Others : Visual disturbances, hearing disturbances.

    Drug Interaction

    ACE inhibitors : diminish the antihypertensive effect of ACE inhibitors.

    Antacids & Sucralfate : delay the absorption of Naproxen.

    Aspirin : increase adverse effects.

    Diuretics : reduce the natriuretic effect of Furosemide and Thiazides.

    Methotrexate : enhance the toxicity of Methotrexate.

    Warfarin : increase the risk of GI bleeding.

    Selective Serotonin Reuptake Inhibitors (SSRI) : increase the risk of GI bleeding.

    Pregnancy & Lactation

    US FDA pregnancy category of Naproxen is C. So, Naproxen should be avoided in pregnancy & lactation unless the potential benefits to the other outweigh the possible risks to the fetus.

    Storage Condition

    Keep in a dry place away from light & heat. Keep out of the reach of children.

    How Supplied

    Nipoxen Tablet : Each box contains 50 tablets in Alu-PVC blister pack.

    Nipoxen 500 SR Tablet : Each box contains 30 tablets in Alu-PVC blister pack.

  • Composition

    Nipoxen 250 Tablet : Each tablet contains Naproxen BP 250 mg.

    Nipoxen 500 SR Tablet : Each sustained release tablet contains Naproxen BP 500 mg.
  • Indication

    Nipoxen (Naproxen) is indicated for the relief of sign and symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendonitis, bursitis & acute gout. It is also indicated for the management of primary dysmenorrhea & pain.
  • Dosage & Administration

    Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis : The usual dose is 500-1000 mg daily in two divided doses after meals.

    Management of pain, primary dysmenorrhea, acute tendonitis & bursitis : Recommended starting dose is 500 mg followed by 500 mg every 12 hours or 250 mg every 6-8 hours. The initial total daily dose should not exceed 1250 mg and thereafter, the total daily dose should not exceed 1000 mg.

    Acute gout : Recommended starting dose is 750 mg followed by 250 mg every 8 hours until the attack has subsided.

  • Contraindication

    Nipoxen is contraindicated in patients with known hypersensitivity to Naproxen. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.
  • Precaution

    Nipoxen is contraindicated in patients with known hypersensitivity to Naproxen. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.
  • Side Effects

    Most frequently reported side effects include following :
    Gastrointestinal : Heartburn, abdominal pain, nausea, diarrhea, dyspepsia.
    Central Nervous System :Headache, vertigo, drowsiness.
    Dermatological :Pruritus (itching), purpura.
    Cardiovascular : Edema, palpitation.
    Others : Visual disturbances, hearing disturbances.
  • Drug Interaction

    ACE inhibitors : diminish the antihypertensive effect of ACE inhibitors.

    Antacids & Sucralfate : delay the absorption of Naproxen.

    Aspirin : increase adverse effects.

    Diuretics : reduce the natriuretic effect of Furosemide and Thiazides.

    Methotrexate : enhance the toxicity of Methotrexate.

    Warfarin : increase the risk of GI bleeding.

    Selective Serotonin Reuptake Inhibitors (SSRI) : increase the risk of GI bleeding.

  • Overdose

  • Pregnancy & Lactation

    US FDA pregnancy category of Naproxen is C. So, Naproxen should be avoided in pregnancy & lactation unless the potential benefits to the other outweigh the possible risks to the fetus.
  • Storage Condition

    Keep in a dry place away from light & heat. Keep out of the reach of children.
  • How Supplied

    Nipoxen Tablet : Each box contains 50 tablets in Alu-PVC blister pack.

    Nipoxen 500 SR Tablet : Each box contains 30 tablets in Alu-PVC blister pack.